RECOVERY OF NEUROMUSCULAR FUNCTION AFTER INFUSION OR INTERMITTENT BOLUS DOSES OF ATRACURIUM OR VECURONIUM

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Recovery of neuromuscular function after infusion or intermittent bolus doses of atracurium or vecuronium.

Neuromuscular block and postoperative recovery of grip strength and peak expiratory flow (PEF) were compared in patients receiving atracurium or vecuronium administered by continuous infusion or intermittent bolus doses. The same total dose of atracurium (0.92-0.98 mg kg-1) or vecuronium (0.16-0.18 mg kg-1) was given by both methods. A similar degree of neuromuscular block was attained in all g...

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Neuromuscular blocking effects of atracurium, vecuronium and pancuronium during bolus and infusion administration.

The potencies of atracurium, vecuronium and pancuronium were compared using bolus injections and continuous infusions. The sizes of the bolus injections were based on previously determined cumulative dose-response relationships. Dose requirements for 90% and 50% sustained blockade were estimated by use of continuous infusion, and the corresponding plasma concentrations were measured for vecuron...

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Reappearance of the train-of-four after neuromuscular blockade induced with tubocurarine, vecuronium or atracurium.

The characteristics of train-of-four recovery after atracurium or vecuronium were studied, under enflurane anaesthesia, and compared with those associated with tubocurarine-induced blockade. Ten patients each received vecuronium 0.1 mg kg-1, atracurium 0.5 mg kg-1 or tubocurarine 0.5 mg kg-1. Neuromuscular blockade was calculated as the percent depression of the first twitch, and was determined...

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Accelerated recovery from combined atracurium-vecuronium neuromuscular block.

Patients given combinations of non-depolarizing neuromuscular blocking drugs have been reported to recover from neuromuscular block more rapidly than patients given a single drug. This study was designed to assess if this phenomenon occurred with the combination of atracurium and vecuronium. During nitrous oxide-fentanyl anaesthesia, 30 adult patients were allocated randomly to receive atracuri...

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Atracurium or vecuronium for MHS patients?

CORRESPONDENCE ATRACURIUM OR VECURONIUM FOR MHS PATIENTS? Sir,—I am writing in regard to comments made by Hunter [1] in her review entitled "Adverse Effects of Neuromuscular Blocking Drugs ", on the use of vecuronium and atracurium in malignant hyperthermia-susceptible (MHS) patients. She states that "satisfactory use of both agents has been reported in patients susceptible to malignant hyperpy...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 1989

ISSN: 0007-0912

DOI: 10.1093/bja/62.3.269